Exposure to misinformation can affect citizens’ beliefs, political preferences, and compliance with government policies. However, little is known about how to reduce susceptibility to misinformation in a sustained manner outside controlled environments, particularly in the Global South. We evaluate an intervention in South Africa that encouraged individuals to consume biweekly fact-checks—as text messages or podcasts—via WhatsApp for six months. The intervention induced substantial consumption and internalization of fact-checks, while increasing participants’ ability to discern political and health misinformation upon exposure—especially when consumption was financially incentivized. Fact-checks that could be quickly consumed via short text messages or via podcasts with empathetic content were most impactful; short messages further increased government approval and compliance with COVID-19 policies. Conversely, we find limited effects on news consumption choices. Our results demonstrate the benefits of inducing sustained exposure to fact-checks, but highlight the difficulty of shifting broader media consumption patterns.